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鹽酸埃克替尼上市后，深入推進(jìn)臨床研究，助力中國肺癌研究走上國際舞臺，開展了80多項(xiàng)學(xué)術(shù)研究，包括一線治療研究、肺癌伴腦轉(zhuǎn)移研究、EGFR狀態(tài)不明患者研究、EGFR21外顯子敏感突變加量研究、與化療聯(lián)合的研究、術(shù)后輔助治療研究等，發(fā)表SCI論文200多篇，影響因子700多分，并在ASCO、WCLC、ESMO等國際學(xué)術(shù)會議上報告、展示。
鹽酸埃克替尼改變了我國晚期肺癌治療指南，樹立了一線治療標(biāo)準(zhǔn)，形成了埃克替尼在晚期非小細(xì)胞肺癌臨床應(yīng)用的專家共識，被納入MIMS 《惡性腫瘤用藥指南》、國家衛(wèi)生計劃生育委員會2018《中國原發(fā)性肺癌診療規(guī)范》、CSCO 2019原發(fā)性肺癌診療指南、衛(wèi)健委《2019腫瘤用藥指南原則》等。
- Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial
- Icotinib versus whole-brain irradiation in patients with EGFR-mutant non-small-cell lung cancer and multiple brain metastases (BRAIN): a multicentre, phase 3, open-label, parallel, randomised controlled trial
- First-line icotinib versus cisplatin/pemetrexed plus pemetrexed maintenance therapy for patients with advanced EGFR mutation-positive lung adenocarcinoma (CONVINCE): a phase 3, open-label, randomized study
- Icotinib in Patients with Pretreated Advanced Esophageal Squamous Cell Carcinoma with EGFR Overexpression or EGFR Gene Amplification: A Single-Arm, Multicenter Phase 2 Study
- Effective treatment with icotinib in lung adenocarcinoma with EGFR and ALK co-alterations and brain metastasis
- A single-arm, multicenter, safety-monitoring, phase IV study of icotinib in treating advanced non-small cell lung cancer (NSCLC)
- Combination of icotinib and chemotherapy as first-line treatment for advanced lung adenocarcinoma in patients with sensitive EGFR mutations: A randomized controlled study
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